Bioinformatics Study of Cymbopogon citratus as Active Compounds
Abstract
Lemongrass is a tropical plant that contains many active compounds in it. Active compounds consisting of volatile organic compounds with various structural forms and properties. This indicator really determines the character and role. Among them can cure diseases for humans and some also function as a distinctive aroma producer. These are all influenced by these structures, giving rise to these characteristics which have been studied by many scientists from all over the world by observing their structures to see the activity they cause. This study intends to prove the active compounds computationally by tracing the names of the compounds contained and scanning them to some well-known software such as Chemoffice. The information obtained is presented in an easy to understand tabular form.
References
E.A. Carlini, J.D.P. Contar, A.R. Silva-Filho, Pharmacology of lemongrass (Cymbopogon citratus Stapf) I. Effects of teas prepared from the leaves on laboratory animals, J. Ethnopharmacol. 17 (1986) 37–64.
M.S.C. Ferreira, M.C. Fonteles, Aspectos etnobotânicos e farmacológicos do Cymbopogon citratus Stapf (capim limão), Revista Brasil. Farmácia 70 (1989) 94–97.
D.H. Grayson, Monoterpenoids, Nat. Prod. Rep. 15 (1998) 435–439.
P.L. Crowell, Prevention and therapy of cancer by dietary monoterpenes, J. Nutr. (1999) 129–775.
J.J. Mills, R.S. Chari, I.J. Boyer, M.N. Gould, R.L. Jirtle, Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol, Cancer Res. (1995) 955–979.
S. Carnesecchi, Y. Schneider, J. Ceraline, B. Duranton, F. Gosse, N. Seller, F. Raul, Geraniol, a component of plant essential oils inhibit growth and polyamine synthesis in human colon cancer cells, J. Pharm. Exp. Ther. 197 (2001) 298.
E.M. Elgendy, Epoxidation reactions of natural limonene piperine and piperic acid as intercalative alkylating agents for DNA, Boll. Chim. Farm. 27 (1997) 36– 532.
E.M. Elgendy, Photooxygenation of natural limonene, Chim. Pharm J. (1998) 50–225.
A. Méou, M.A. Garcia, P. Brun, Oxygen transfer mechanism in the Mn-salen catalysed epoxidation of olefins, J. Mol. Catal. A Chem. 23 (1999) 138–221.
E.M. Elgendy, Photooxygenation of natural ã-terpinene, Boll. Chim. Farm. (2004) 143–337. [11] N.W.A. Geraghty, Photochemistry, in: I. Dunkin (Ed.), London: Royal Soc. Chem. 27 (2005) 35–116.
S. Richter, B. Gatto, D. Fabris, K.I. Takao, S. Kobayashi, S.M. Palumbo, Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action, Nucleic Acids Res. 31 (2003) 5149.
E.M. Elgendy, S.A. Khayyat, Oxidation studies on some natural monoterpenes: citral, pulegone, and camphene, Russ. J. Org. Chem. 44 (2008) 814.
Carbone, C., Martins-Gomes, C., Caddeo, C., Silva, A.M., Musumeci, T., Pignatello, R., Puglisi, G., Souto, E.B., 2018. Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles. Int. J. Pharm. 548, 217–226.
Sampaio, A.C., Aires, A., Souto, E.B., Silva, A.M., 2017. Essential oils, polyphenols and glycosides: secondary plant metabolites against microbes. Frontiers in clinical drug research-anti infectives. vol. 3, Chapter 4. Bentham Science Publishers, pp. 139–186.
Pereira, I., Severino, P., Santos, A.C., Silva, A.M., Souto, E.B., 2018. Linalool bioactive properties and potential applicability in drug delivery systems. Colloids Surf., B Biointerfaces 171, 566–578.
Severino, P., Andreani, T., Chaud, M.V., Benites, C.I., Pinho, S.C., Souto, E.B., 2015. Essential oils as active ingredients of lipid nanocarriers for chemotherapeutic use. Curr. Pharm. Biotechnol. 16, 365–370.
Astani, A., Schnitzler, P., 2014. Antiviral activity of monoterpenes beta-pinene and limonene against Herpes simplex virus in vitro. Iran. J. Microbiol. 6, 149–155.
Edris, A.E., 2007. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytother. Res. 21, 308–323.
Bhalla, Y., Gupta, V.K., Jaitak, V., 2013. Anticancer activity of essential oils: a review. J. Sci. Food Agric. 93, 3643–3653.
Pereira, S.L., Marques, A.M., Sudo, R.T., Kaplan, M.A.C., Zapata-Sudo, G., 2013. Vasodilator activity of the essential oil from aerial parts of Pectis brevipedunculata and its main constituent citral in rat aorta. Molecules 18, 3072–3085.
Marcus, J., Klossek, M.L., Touraud, D., Kunz, W., 2013. Nano-droplet formation in fragrance tinctures. Flavour Fragrance J. 28, 294–299.
Hagvall, L., Bäcktorp, C., Svensson, S., Nyman, G., Börje, A., Karlberg, A.-T., 2007. Fragrance compound geraniol forms contact allergens on air exposure. identification and quantification of oxidation products and effect on skin sensitization. Chem. Res. Toxicol. 20, 807–814.
Hagvall, L., Brared Christensson, J., 2014. Cross-reactivity between citral and geraniol - can it be attributed to oxidized geraniol? Contact Dermatitis 71, 280–288.
Rudbäck, J., Islam, N., Nilsson, U., Karlberg, A.T., 2013. A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry. J. Sep. Sci. 36, 1370–1378.
Weng, D.C.J., Latip, J.B., Hasbullah, S.A.B., Sastrohamidjojo, H., 2015. Separation of geraniol from citronellol by selective oxidation of geraniol to geranial. Sains Malaysiana 44, 1183–1188.
